PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. We used individual level genotype data generated from 1, Brabet P. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ubiquitous neuropeptide of the vasoactive intestinal peptide. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. J Clin Invest –, The purpose of this review is to present recent data on the effects of PACAP, VIP, VPAC1R, VPAC2R and PAC1R on the modulation of appetite. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ubiquitous neuropeptide of the vasoactive intestinal peptide. PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. Philippe Brabet. Brabet P. Philippe Brabet. . Brabet P. In this study, we performed biological pathway-based GWA analysis for BMI and body fat mass. PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance.